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Methadone is a potent synthetic analgesic that works as a complete µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a complete MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins thru the discharge of neurotransmitters concerned in pain transmission. It additionally has some of precise traits that have caused its expanded use inside the final two decades; in particular, methadone has a lower chance of neuropsychiatric toxicity as compared to different opioids (due to an absence of active metabolites), minimum accumulation in renal failure, true bioavailability, low cost, and a long period of action.Due to its particular mechanism of action, methadone is particularly beneficial for the management of hard to deal with pain syndromes which includes neuropathic pain and cancer ache requiring better and greater frequent doses of shorter-performing opioids.
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