Plasmid DNA Manufacturing Market Size to Cross USD 300 Million by 2026

The global Plasmid DNA Manufacturing Market size is anticipated to around USD 300 million by 2026, this market is anticipated to grow with 20% CAGR during the forecast time period. In the Plasmid DNA Manufacturing Market, The regional segmentation includes current and projected demand in North America, Europe, Asia Pacific, Latin America and the Middle East and Africa.

During the forecast period, the growing growth of the gene therapy market is likely to be seen in demand by plasmid DNA contract manufacturers. In addition, in recent years the demand for cell and gene therapy has increased substantially. According to recent findings from the Alliance of Regenerative Medicine (ARM), the funding of different cell and gene therapies was increased by over 75% year-on-year. Cell and gene therapies have taken place in a league of over 2,600 clinical trials reported to date. The growing demand for these therapies has given vector manufacturers new opportunities.

As a result of strategies such as market players working together, in Europe are expected to see significant growth in the plasmid DNA manufacturing market. For instance, in May 2018, Plasmid Factory GmbH & Co. KG has partnered with Vibalogics GmbH, Sirion-Biotech GmbH, and PROGEN for the development of vector adeno-associated virus (AAV). The goal of this collabration was to make the development of plasmid products simple and the study of recombinant AAVs to meet customers' requirements.

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Advancing Plasmid Manufacturing at Aldevron

Aldevron has developed plasmid DNA in 1998. They initially supplied research material and then extended to custom plasmid DNA for clinical, preclinical, and commercial purposes.
The plasmids needed for viral vectors (AAV, lentivirus), DNA, CAR-T cell therapy, gene editing, cloning, DNA vaccines, personalised cell therapy and other applications have proved their expertise in Aldevron. Companies that seek novel products, including Sarepta for Duchenne's gene therapy and Genprex's lung cancer plasmid DNA, turn to Aldevron to be their plasma DNA suppliers.
It can generate supercoiled, circular, minicroplasma, nanoplasmid and bacmid-plasma DNA and is capable of producing hundreds of grams per lot and hundreds of thousands of large-scale plasmid prepares per day. They will supply plasmid DNA in scientific, industrial and research applications.
To meet different customer requirements, Aldevron manufactures plasmids at different service levels. For high-quality plasmid DNA, the research class is the fastest option. A cost-effective alternative to cGMP is GMP-SourceTM. Their cGMP service provides oversight and process management of highest quality and can support any demand, including parenteral administration.
Aldevron also recently began supplying bulk off-shelf plasmids for AAV and lentiviral vector production. The immediate availability and costs for the manufacture of AAV and LV vectors are significantly reduced by the immediate use of these plasmids and also risk reduction is simplified by a reliable manufacturer of consistent high quality products. The plasmids inventory is also available at the level of research, GMP-SourceTM and cGMP.

Key market players depend on approaches like mergers and acquisitions to boost their product portfolio. For instance, in 2016, the exclusive collaboration for Agilis experimental gene therapy drug AGIL-FA for the treatment of Friedreich's ataxia (FA) was entered into Agilis Biotherapeutics, LLC (AGILis) and Waisman Bia Manufacturing. Similarly, the Aldevron Antibody Development Platform in Germany revealed an expansion plan in March 2019. This proposal has increased the development and laboratory space of the current facility to approximately 4300 square feet.

The guidelines also consider specific organizational structures and compliance skills for early phase studies:

Large companies in pharmaceutical/biotechnology that are likely to supply products in the market
Start-up companies that grow and transition products to phase 1-2 and then to larger organizations or partners
Limited trials for scientific publications by universities and funding agencies

Key Insights

The North America Plasmid DNA Manufacturing market size was over 26 million USD in 2018 and is expected to witness the growth at a CAGR of around 22% from 2019 to 2026.
The market in Asia Pacific is expected to witness faster growth, owing to factors such as increasing government expenditure on healthcare sector in order to facilitate R&D activities.
The cancer market is expected to witness significant growth over the forecast period.

Market Segmentation

Market By Application

Gene Therapy
Vaccinology

Market By Disease

Infectious Disease
Cancer
Genetic Disorder

Market By End use

Research Institute
Biotech Companies

Market By Region

North America
Europe
Asia Pacific
Latin America
Middle East & Africa

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Key Questions Answered in the Report

The report addresses key questions concerning the market evolution and overarching trends shaping global market growth. Some of the key questions answered in the report include-

- What is the overall structure of the market?

- What was the historical value and what is the forecasted value of the market?

- What are the key product level trends in the market?

- What are the market level trends in the market?

- Which of the market players are leading and what are their key differential strategies to retain their stronghold?

- Which are the most lucrative regions in the market space?

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TABLE OF CONTENT

Chapter 1. Industry Overview of Plasmid DNA Manufacturing
1.1 Definition and Scope
1.1.1 Definition of Plasmid DNA Manufacturing
1.1.2 Market Segmentation
1.2 Summary
1.2.1 Market Snapshot
1.3 Global Plasmid DNA Manufacturing Market By Application
1.3.1 Global Plasmid DNA Manufacturing Market Revenue and Growth Rate Comparison By Application (2015-2026)
1.3.2 Gene Therapy
1.3.3 Vaccinology
1.4 Global Plasmid DNA Manufacturing Market By Disease
1.4.1 Global Plasmid DNA Manufacturing Market Revenue and Growth Rate Comparison By Disease (2015-2026)
1.4.2 Infectious Disease
1.4.3 Genetic Disorders
1.4.4 Cancer
1.5 Global Plasmid DNA Manufacturing Market By End Use
1.5.1 Global Plasmid DNA Manufacturing Market Revenue and Growth Rate Comparison By End Use (2015-2026)
1.5.2 Research Institutes
1.5.3 Biotech Companies
1.6 Global Plasmid DNA Manufacturing Market by Regions
1.6.1 Global Plasmid DNA Manufacturing Market Size and Growth Rate Comparison by Regions (2015-2026)
1.6.2 North America Plasmid DNA Manufacturing Market Revenue And Growth Rate (2015-2026)
1.6.3 Europe Plasmid DNA Manufacturing Market Revenue And Growth Rate (2015-2026)
1.6.4 Asia-Pacific Plasmid DNA Manufacturing Market Revenue And Growth Rate (2015-2026)
1.6.5 Latin America Plasmid DNA Manufacturing Market Revenue And Growth Rate (2015-2026)
1.6.6 Middle East & Africa Plasmid DNA Manufacturing Market Revenue And Growth Rate (2015-2026)

Chapter 2. Market Dynamics and Competition Analysis
2.1 Market Drivers
2.2 Restraints and Challenges
2.3 Growth Opportunities
2.4 Porter’s Five Forces Analysis
2.4.1 Low Bargaining Power of Suppliers
2.4.2 Medium Bargaining Power of Buyers
2.4.3 High Threat of Substitute
2.4.4 Low Threat of New Entrants
2.4.5 High Degree of Competition
2.5 Value Chain Analysis
2.6 Cost structure Analysis
2.6.1 Raw Material and Suppliers
2.6.2 Proportion of Manufacturing Cost Structure
2.6.2.1 Raw Material
2.6.2.2 Labor Cost
2.6.2.3 Manufacturing Expense
2.7 Regulatory Compliance
2.8 Competitive Landscape, 2018
2.8.1 Player Positioning Analysis
2.8.2 Key Strategies Adopted By Leading Players

Chapter 3. Manufacturing Plant Analysis
3.1 Revenue and Commercial Date of Global Plasmid DNA Manufacturing Major Manufacturers in 2018
3.2 Manufacturing Plants Distribution of Global Plasmid DNA Manufacturing Major Manufacturers in 2018

Chapter 4. Plasmid DNA Manufacturing Market By Application
4.1 Global Plasmid DNA Manufacturing Revenue by Application
4.2 Gene Therapy
4.2.1 Market Revenue and Growth Rate, 2015 - 2026 (US$ Million)
4.2.2 Market Revenue and Forecast, By Region, 2015 - 2026 (US$ Million)
4.3 Vaccinology
4.3.1 Market Revenue and Growth Rate, 2015 - 2026 (US$ Million)
4.3.2 Market Revenue and Forecast, By Region, 2015 - 2026 (US$ Million)

Chapter 5. Plasmid DNA Manufacturing Market By Disease
5.1 Global Plasmid DNA Manufacturing Revenue by Disease
5.2 Infectious Disease
5.2.1 Market Revenue and Growth Rate, 2015 - 2026 (US$Mn)
5.2.2 Market Revenue and Forecast, By Region, 2015 - 2026 (US$Mn)
5.3 Genetic Disorders
5.3.1 Market Revenue and Growth Rate, 2015 - 2026 (US$Mn)
5.3.2 Market Revenue and Forecast, By Region, 2015 - 2026 (US$Mn)
5.4 Cancer
5.4.1 Market Revenue and Growth Rate, 2015 - 2026 (US$Mn)
5.4.2 Market Revenue and Forecast, By Region, 2015 - 2026 (US$Mn)

Chapter 6. Plasmid DNA Manufacturing Market By End Use
6.1 Global Plasmid DNA Manufacturing Revenue by End Use
6.2 Research Institutes
6.2.1 Market Revenue and Growth Rate, 2015 - 2026 (US$Mn)
6.2.2 Market Revenue and Forecast, By Region, 2015 - 2026 (US$Mn)
6.3 Biotech Companies
6.3.1 Market Revenue and Growth Rate, 2015 - 2026 (US$Mn)
6.3.2 Market Revenue and Forecast, By Region, 2015 - 2026 (US$Mn)

Chapter 7. North America Plasmid DNA Manufacturing Market By Country
7.1 North America Plasmid DNA Manufacturing Market Revenue and Growth Rate, 2015 - 2026 (US$ Million)
7.2 North America Plasmid DNA Manufacturing Market Revenue Share, by Country, 2018 (%)
7.3 U.S.
7.3.1 U.S. Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
7.3.2 U.S. Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
7.3.3 U.S. Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
7.4 Canada
7.4.1 Canada Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
7.4.2 Canada Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
7.4.3 Canada Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)

Chapter 8. Europe Plasmid DNA Manufacturing Market By Country (8)
8.1 Europe Plasmid DNA Manufacturing Market Revenue and Growth Rate, 2015 - 2026 (US$ Million)
8.2 Europe Plasmid DNA Manufacturing Market Revenue Share, By Country, 2018 (%)
8.3 UK
8.3.1 UK Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
8.3.2 UK Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
8.3.3 UK Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
8.4 Germany
8.4.1 Germany Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
8.4.2 Germany Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
8.4.3 Germany Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
8.5 France
8.5.1 France Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
8.5.2 France Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
8.5.3 France Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
8.6 Spain
8.6.1 Spain Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
8.6.2 Spain Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
8.6.3 Spain Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
8.7 Italy
8.7.1 Italy Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
8.7.2 Italy Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
8.7.3 Italy Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
8.8 Rest of Europe
8.8.1 Rest of Europe Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
8.8.2 Rest of Europe Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
8.8.3 Rest of Europe Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)

Chapter 9. Asia-Pacific Plasmid DNA Manufacturing Market By Country
9.1 Asia-Pacific Plasmid DNA Manufacturing Market Revenue and Growth Rate, 2015 - 2026 (US$ Million)
9.2 Asia-Pacific Plasmid DNA Manufacturing Market Revenue Share Comparison, By Country, 2015 & 2026 (%)
9.3 China
9.3.1 China Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
9.3.2 China Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
9.3.3 China Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
9.4 Japan
9.4.1 Japan Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
9.4.2 Japan Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
9.4.3 Japan Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
9.5 India
9.5.1 India Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
9.5.2 India Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
9.5.3 India Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
9.6 Australia
9.6.1 Australia Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
9.6.2 Australia Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
9.6.3 Australia Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
9.7 South Korea
9.7.1 South Korea Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
9.7.2 South Korea Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
9.7.3 South Korea Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
9.8 Rest of Asia-Pacific
9.8.1 Rest of Asia-Pacific Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
9.8.2 Rest of Asia-Pacific Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
9.8.3 Rest of Asia-Pacific Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)

Chapter 10. Latin America Plasmid DNA Manufacturing Market By Country
10.1 Latin America Plasmid DNA Manufacturing Market Revenue and Growth Rate, 2015 - 2026 (US$ Million)
10.2 Latin America Plasmid DNA Manufacturing Market Revenue Share, by Country, 2018 (%)
10.3 Brazil
10.3.1 Brazil Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
10.3.2 Brazil Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
10.3.3 Brazil Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
10.4 Mexico
10.4.1 Mexico Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
10.4.2 Mexico Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
10.4.3 Mexico Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
10.5 Rest of Latin America
10.5.1 Rest of Latin America Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
10.5.2 Rest of Latin America Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
10.5.3 Rest of Latin America Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)

Chapter 11. Middle East & Africa Plasmid DNA Manufacturing Market By Country
11.1 Middle East & Africa Plasmid DNA Manufacturing Market Revenue and Growth Rate, 2015 - 2026 (US$ Million)
11.2 Middle East & Africa Plasmid DNA Manufacturing Market Revenue Share Comparison, By Countries, 2018 (%)
11.3 Saudi Arabia
11.3.1 Saudi Arabia Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
11.3.2 Saudi Arabia Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
11.3.3 Saudi Arabia Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
11.4 UAE
11.4.1 UAE Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
11.4.2 UAE Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
11.4.3 UAE Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)
11.5 Rest of Middle East & Africa
11.5.1 Rest of Middle East & Africa Plasmid DNA Manufacturing Market Revenue and Forecast By Application, 2015 - 2026 (US$ Million)
11.5.2 Rest of Middle East & Africa Plasmid DNA Manufacturing Market Revenue and Forecast By Disease, 2015 - 2026 (US$ Million)
11.5.3 Rest of Middle East & Africa Plasmid DNA Manufacturing Market Revenue and Forecast By End Use, 2015 - 2026 (US$ Million)

Chapter 12. Major Manufacturers Analysis of Plasmid DNA
12.1 Cobra Biologics Limited
12.1.1 Business Overview
12.1.2 Company Profile
12.1.3 Cobra Biologics Limited 2018 Financial Analysis
12.1.4 Cobra Biologics Limited 2018 Plasmid DNA Business Region Distribution Analysis
12.1.5 Product Segment
12.1.6 Marketing Strategy and Recent Development
12.2 Novasep Inc.
12.2.1 Business Overview
12.2.2 Company Profile
12.2.3 Novasep Inc. 2018 Financial Analysis
12.2.4 Novasep Inc. 2018 Plasmid DNA Business Region Distribution Analysis
12.2.5 Product Segment
12.2.6 Marketing Strategy and Recent Development
12.3 Spark Therapeutics, Inc.
12.3.1 Business Overview
12.3.2 Company Profile
12.3.3 Spark Therapeutics, Inc. 2018 Financial Analysis
12.3.4 Spark Therapeutics, Inc. 2018 Plasmid DNA Business Region Distribution Analysis
12.3.5 Product Segment
12.3.6 Marketing Strategy and Recent Development
12.4 FUJIFILM Diosynth Biotechnologies Inc.
12.4.1 Business Overview
12.4.2 Company Profile
12.4.3 FUJIFILM Diosynth Biotechnologies Inc. 2018 Financial Analysis
12.4.4 FUJIFILM Diosynth Biotechnologies Inc. 2018 Plasmid DNA Business Region Distribution Analysis
12.4.5 Product Segment
12.4.6 Marketing Strategy and Recent Development
12.5 Cell and Gene Therapy Catapult
12.5.1 Business Overview
12.5.2 Company Profile
12.5.3 Cell and Gene Therapy Catapult 2018 Plasmid DNA Sales, Ex-factory Price, Revenue, Gross Margin Analysis
12.5.4 Cell and Gene Therapy Catapult 2018 Plasmid DNA Business Region Distribution Analysis
12.5.5 Product Segment
12.5.6 Marketing Strategy and Recent Development
12.6 Kaneka Eurogentec S.A (KANEKA)
12.6.1 Business Overview
12.6.2 Company Profile
12.6.3 Kaneka Eurogentec S.A 2018 Plasmid DNA Sales, Ex-factory Price, Revenue, Gross Margin Analysis
12.6.4 Kaneka Eurogentec S.A 2018 Plasmid DNA Business Region Distribution Analysis
12.6.5 Product Segment
12.6.6 Marketing Strategy and Recent Development
12.7 UniQure N.V.
12.7.1 Business Overview
12.7.2 Company Profile
12.7.3 uniQure N.V. Financial Analysis, 2019
12.7.4 uniQure N.V Plasmid DNA Business Region Distribution Analysis, 2019
12.7.5 Product Segment
12.7.6 Marketing Strategy and Recent Development
12.8 Lonza
12.8.1 Business Overview
12.8.2 Company Profile
12.8.3 Lonza Financial Analysis, 2018
12.8.4 Lonza Plasmid DNA Business Region Distribution Analysis, 2018
12.8.5 Product Segment
12.8.6 Marketing Strategy and Recent Development
12.9 Merk KgaA
12.9.1 Business Overview
12.9.2 Company Profile
12.9.3 Merk KgaA Financial Analysis, 2018
12.9.4 Merk KgaA Plasmid DNA Business Region Distribution Analysis, 2018
12.9.5 Product Segment
12.9.6 Marketing Strategy and Recent Development

Chapter 13. Research Approach
13.1 Methodology
13.1.1 Research Programs/Design
13.1.2 Market Size Estimation
13.1.3 Market Breakdown and Data Triangulation
13.2 Data Source
13.2.1 Secondary Sources
13.2.2 Primary Sources

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