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Psilocybin Mushrooms have been used for centuries throughout ancient Mayan and Aztec cultures. Psilocybin mushrooms (aka “magic mushrooms” or “shrooms”) are fungi that contain psilocybin, a naturally occurring psychedelic compound. More than 180 species of mushrooms contain psilocybin or its derivative psilocin. Psilocybin mushrooms have a long history of use in Mesoamerican spiritual and religious rituals, and are one of the most popular recreational psychedelics in the Canada, U.S, and Europe.