Coronavirus Disease 2019 (COVID-19) Treatment & Management
COVID-19 is an infectious disease that is caused by the most recently discovered coronavirus. COVID-19 is now a pandemic affecting many countries globally. The common symptoms of COVID-19 are fever, dry cough, and tiredness. Whereas, some patients may have aches and pains, nasal congestion, sore throat, or diarrhea. These symptoms are generally mild and begin gradually. Also, some people become infected but only have very mild symptoms.
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More than 227,000 people have died with Covid-19, but there are still no drugs proven to help doctors treat the disease.
So how far are we from these life-saving medicines?
What work is being done to find treatments?
More than 150 different drugs are being researched around the world. Most are existing drugs that are being trialled against the virus.
- The World Health Organization (WHO) has launched the Solidarity trial aimed at assessing the most promising treatments
- The UK says its Recovery trial is the world's biggest, with more than 5,000 patients already taking part
- And multiple research centres around the world are attempting to use survivors' blood as a treatment
What types of drugs might work?
There are three broad approaches being investigated:
- Antiviral drugs that directly affect the coronavirus's ability to thrive inside the body
- Drugs that can calm the immune system - patients become seriously ill when their immune system overreacts and starts causing collateral damage to the body
- Antibodies, either from survivors' blood or made in a lab, that can attack the virus
Why do we need treatment?
- The most obvious reason for wanting treatment is it will save lives, but it could also allow some lockdown measures to be lifted.
- Having an effective treatment would, in essence, make coronavirus a milder disease.
- If it stopped people who were admitted to hospital from needing ventilation, then there would be less risk of intensive care units being overwhelmed, so controls on people's lives may not need to be as strict.
Can HIV drugs treat coronavirus?
- There has been much talk, but little evidence, that a pair of HIV drugs - lopinavir and ritonavir - would be effective at treating coronavirus.
Can malaria drugs stop coronavirus?
- Malaria drugs are part of both the Solidarity and Recovery trials.
- Chloroquine, and a related derivative, hydroxychloroquine, may have antiviral and immune-calming properties.
What about immune drugs?
If the immune system overreacts to the virus then it can cause inflammation throughout the body. This is helpful for rallying the immune system to fight the infection, but too much can cause collateral damage throughout body and can be fatal.
Top 10 Companies Working For the most promising coronavirus drug !!
- Applied DNA Sciences, Inc
- Codagenix
- Evvivax
- Generex Biotechnology Corporation
- GeoVax Labs, Inc.
- MIGAL Galilee Research Institute
- Moderna Therapeutics
- Novavax
- Takis Biotech
- Zydus Cadila
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Reference
- theinsightpartners.com
- bbc.com