Development Of CRISPR As A Prophylactic Strategy To Combat Novel Coronavirus And Influenza
CRISPR-based genetic screens have helped scientists identify genes that are key players in sickle-cell anemia, cancer immunotherapy, lung cancer metastasis, and many other diseases. However, these genetic screens are limited in scope: They can only edit or target DNA. For many regions of the human genome, targeting DNA may not be effective, and other organisms, such as RNA viruses like coronavirus or flu, cannot be targeted at all with existing DNA-targeting CRISPR screens.
Once overshadowed by DNA-targeting CRISPR systems, RNA-targeting CRISPR systems are stepping into the light. What’s more, RNA-targeting CRISPR systems are advancing on important applications for which they are uniquely well suited. For example, they can silence gene expression at the transcriptional level, which is advantageous if the corresponding targets at the genomic level are hard to access. Also, RNA-targeting CRISPR systems can be effective in targeting RNA viruses such as the coronaviruses or influenza viruses.
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What is Crispr technology and how does it work?
CRISPR and CRISPR-Associated (Cas) Genes is a genome editing tool that enables the researchers to make changes in the DNA. CRISPR-Cas9 stands for clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9. In recent years the CRISPR and CRISPR-Associated (Cas) Genes has gained lot of popularity as it offers it is cheaper, faster, accurate, and more efficient genome editing methods.
The CRISPR-Cas9 system works similarly in the lab. Researchers create a small piece of RNA with a short "guide" sequence that attaches (binds) to a specific target sequence of DNA in a genome. The RNA also binds to the Cas9 enzyme. As in bacteria, the modified RNA is used to recognize the DNA sequence, and the Cas9 enzyme cuts the DNA at the targeted location. Although Cas9 is the enzyme that is used most often, other enzymes (for example Cpf1) can also be used. Once the DNA is cut, researchers use the cell's own DNA repair machinery to add or delete pieces of genetic material, or to make changes to the DNA by replacing an existing segment with a customized DNA sequence.
What are the different types And Application of Crispr?
Product Type (Vector-based Cas, DNA-free Cas) And Application (Genome Engineering, Disease models, Functional Genomics, Knockdown/activation, Others
Who Are end users Of Crispr..??
Biotechnology and Pharmaceutical Companies, Academic and Government Research Institutes, Contract Research Organizations)
Who Are Top Players In CRISPR & CRISPR-associated (Cas) Genes..??
Merck KGaA, Addgene, CRISPR THERAPEUTICS, Thermo Fisher Scientific, Mirus Bio, Editas Medicine, Takara Bio USA, Horizon Discovery Group, Dharmacon, Intellia Therapeutics, Inc.
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