August 19, 2021

DIFFERENCES BETWEEN CONVENTIONAL & CONDITIONAL KNOCKOUT MOUSE MODEL

When it comes to figuring out the variation between conventional and conditional knockout mouse models, it is vital to evaluate different factors. Therefore in this post, we are going to solve all your issues through deep information about Traditional and conditional knockouts. Check out the information shared in the below section to consider the most advanced mouse model in your laboratory.

The Basics of Conventional and Conditional Knockouts

Conventional knockouts are the oldest animal models based on artificially impaired genes. On the other end, conditional knockouts are modern models that only focused on specific tissues or organs. For studying different diseases related to the liver, the researcher can easily make the most of conditional knockout specific organs. This way, you can also get the most accurate results of treatment.

The Limitations of Traditional Conventional Knockout Methods

Conventional knockout can affect all types of cells that are utilized in the embryo development process. Furthermore, all tissues remain active in the conventional knockout mouse model. Therefore, researchers fail to figure out the reaction of treatment in different stages of activation and deactivation.

Why Makes New Conditional Knockout Superior?

As conditional knockouts had more capabilities, it makes them superior to conventional knockouts. With a conditional knockout mouse model, you can learn about certain tissue types at different intervals. However, new-age technologies (CRISPR) can be used to minimize the wastage of time as compared to the traditional procedure.

The Pros of Advanced Gene Editing with Conditional Knockouts

After the development of CRISPR/Cas9, Conditional Knock Out Mouse Model have become a top choice for researchers. It enables researchers to carry out their studies in a more simple and efficient manner without consuming an ample amount of time.

Conclusion

In the end, it could be stated now that it is better to opt for conditional knockout than traditional. This is because new technologies make it easier to get a better result in a more convenient manner.